Jan 4, 2018 22:08
6 yrs ago
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English term
Dose-Escalation DLTs
English to Russian
Medical
Medical: Pharmaceuticals
Dose-Escalation DLTs
A DLT is defined as an AE or abnormal laboratory value assessed as unrelated to disease progression, intercurrent illness, or concomitant medications, occurring in Cycle 1 (21 days) meeting any of the following criteria.
Table :
DLTs for ХХХХ
Hematologic
Non-hematologic
Grade 4 neutropenia lasting > 7 days.
Febrile neutropenia (defined as absolute neutrophil count [ANC] 1 hour).
Grade 3 neutropenic infection.
Grade 3 thrombocytopenia with bleeding.
Grade 4 thrombocytopenia.
Grade 4 (life-threatening) anemia
Grade 5 adverse events (death)
Grade 4 toxicity
A DLT is defined as an AE or abnormal laboratory value assessed as unrelated to disease progression, intercurrent illness, or concomitant medications, occurring in Cycle 1 (21 days) meeting any of the following criteria.
Table :
DLTs for ХХХХ
Hematologic
Non-hematologic
Grade 4 neutropenia lasting > 7 days.
Febrile neutropenia (defined as absolute neutrophil count [ANC] 1 hour).
Grade 3 neutropenic infection.
Grade 3 thrombocytopenia with bleeding.
Grade 4 thrombocytopenia.
Grade 4 (life-threatening) anemia
Grade 5 adverse events (death)
Grade 4 toxicity
Proposed translations
(Russian)
4 | ДЛТ при повышении дозы | Natalie |
4 | ограничивающая дозу токсичность при увеличении дозы | Pavel Nikonorkin |
Proposed translations
6 mins
Selected
ДЛТ при повышении дозы
дозолимитирующая токсичность (ДЛТ) при эскалации/повышении дозы
4 KudoZ points awarded for this answer.
2 mins
ограничивающая дозу токсичность при увеличении дозы
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Note added at 3 mins (2018-01-04 22:12:10 GMT)
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DLT = Dose Limiting Toxicities
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